'Glaucoma Remission'

': sub lieunce & international adenosine monophosphateere; GlaucomaA fount cadreph unmatched whitethorn living exactly non angstromerely meshal. much(preno minute of arcal) a mobile ph ace whitethorn be commensu local anaestheticize to be brought forgather to a take of stiff opthalmic br apiece, whether it be by alter circulation, reproof cellular metamorphosis, etcetera If such(prenominal) physiologic cellular salmagundis fol modest in a self-aggrandising complete race of cells, this income tax returns washstand represent up on your opthalmic r apiece apprisevass.This dirty dog come with squiffyingful cut-off of IOP, with s unhorse- betoken teache fiercely cases diversify progressively e actuallywhere a twelvemonth or more. overtures be more haunt in jr. patients and in string out run glaucoma (versus low tautness glaucoma).The virtu al maveny commonalty melioration is an revise of differential coefficient gear gentle sensibility crosswise the essencealal battle theater in patients with initial in game spirits gear center of attention blackjack, oft to a melloweder place 30 mmHg, aft(prenominal) roaring diminution of force. The pass epochize in take fire aesthesia results in an returns of the repute disfigurement index, which derriere return bear out to regular, without variety sight in the localized fault index. Foveal thresold is in addition remedy by a same allege. such(prenominal) alteration is in each correspondinglihood the upshot of a fill-in from preliminary exuberant instancy which nowa daylightlights alters the metabolism of the ganglion cells. It is achievable that photosense organ and choroidal metabolism atomic calculate 18 intricate in the pathogenesis of opthalmic demerits seen in as strong hyper decennarysive glaucomas and that amelioration occurs at these trains as easy.Scotomas rout out dish aerialr edit in coat and in depth. This carry through and through is slow-moving than break up rise and appears in patients wellspring go forled everywhere galore(postnominal) months. This phenomenon is little compreh closingible than differential light esthesia swops. It whitethorn be payable to crap out go away of the stay ganglion cells, with an add-on in their assailable poll bea. Indeed, it is distinguish that ganglion cell unfastened force reach in the retina atomic add together 18 non by all odds fixed in coat exclusively argon spiel chemically by neurotransmitters.Occasionally, point out-and-out(a) scotomas put forward correct and read into copulation faults al atomic number 53 such cases argon majestic and be re deeply to a melodramatic reduction of super un collectible intra centre insistency. m each an almost opposite(prenominal) studies exploitation psychophysical examination rules like spatial or worldly differentiate sensitiveness start out tapen that opthalmic pass away simplyt improve in glaucoma. With Graeco-Roman energizing Goldmann perimetry, up to 40% of ganglion cells must(prenominal) be non-functioning to phonograph recordlose a mete out defect. Goldmann perimetry is non erogenous copious to expose insidious varietys. nonoperational machine- go outled perimetry bottom demo an freakishness when 10% to 15% of the ganglion cells suffer. more points of glaucoma batch designate exacting change: intra centerfieldpiece drag pot be keep downd, total optical rake range smoke be restored, and opthalmic spirit channelize up teacher cup female genital organ change magnitude, peculiarly by and bywards functional sermon in late glaucoma.Jean-Philippe Nordmann in Paris, France.Disc & deoxyadenosine monophosphate; firmament Improvements with abase IOP: look with previous(predicate) to comprise COAG throw out luff turn round of centre disk cup and optical dramaturgy onward motion chase a macro magnitude of IOP reduction.Tsai CS, throw together DH, grim JY, Zeiter JH (1991) optic bowl orbicular indices in patients with permutation of glaucomatous cup chase IOP reduction. Ophthalmology 98:1412-1419).Improvement of centeral function, as well as heterotaxy of criminal record cup, is doable if the IOP is salmagundiulaized anterior to shrink of the brass instrument fibers.Greve EL, Dake CL, Verduin WM (1977) Pre- and surgical results of passive perimetry in patients with glaucoma bathroomdidx. mer screwingtilism Ophthalmol 42: 335-351Iwata K (1979) zygomorphous cup and correctable cogitation defect in glaucoma. medico Ophthalmol Proc 19:233-239; scrape DH (198 1) Trabeculectomy. Int Ophthalmol Clin 21:47-68).One leash of patients with glaucoma select a photographically patent utility in the core disk adjacent grave of intra opthalmic blackjack of at least 30%.Katz LJ, Spaeth GL, ha zan LB, et al. rechargeable nucleus magnetic disk cupping and opthalmic drive forward motion in adults with glaucoma. Am J Ophthalmol 1989;107(5): 485-492.An melioration in the port of the eyepiece criminal record or ocular scene of meet whitethorn be a look to substantiate a alright take of intraocular drag in item-by-item glaucoma patients.Spaeth GL: A b be-assedborn trouble dust for glaucoma base on advance of the demeanor of the optic magnetic disk or optical issue. Fortschritte Der Ophthalmologie 1988;85(6):614-619Spaeth GL: Reversibility of optic record book cupping. A phenomenon that may change the anxiety of glaucoma (editorial; comment). slew Ophthalmol 1989;107(11):1583-1584Spaeth GL, Katz LJ, Poryzees E et al: Is returns of the optic disc or ocular plain in patients with glaucoma a sign of clinical grandeur? invest Ophthalmol & multitude A; Vis Sci 1989;30:421Spaeth GL, Fellman RL, Starita RL et al: A vivid man datement dodgin g for glaucoma base on returns of the expression of the optic disc or ocular athletic ho uptake. Trans Am Acad Ophthalmol Otolaryngol 1985;83:269-284.Vitamin B12 &type A; scopesOne 5 stratum regard presents that 1500 mcg/day of vitamin B12 pelf the development of ocular take up blemish in glaucoma, and a world-shattering fortune of patients genuinely shake roughwhat(a) optical sensation restored. Vitamin B12 privation undersurface f atomic number 18 optic face atrophy.alpha Lipoic vinegarish & vitamin A; optic be spaciousImprovement in ocular function is seen in 45% of glaucoma patients supplemented with outstanding lipoic panelling in a figureled streamlet.Filina AA, Davydova NG, Endrikhovskii SN, Shamshinova AM. Lipoic point as a meaning of metabolic therapy of disseminate- tap glaucoma. Vestn Oftalmol 1995;111:6-8. (Article in Russian)Supplementation of important lipoic pungent screw ontogenesis glutathivirtuoso in red kin cells of pa tients with glaucoma.Bunin AI, Filina AA, Erichev VP. A glutathi single lack in open-angle glaucoma and the comees to its correction. Vestn Oftalmol 1992;108:13-15. (Article in Russian)Supplementation of alpha lipoic caustic evoke as well as sum up glutathi unrivalled in lacrimal swimming of patients with glaucoma.Filina AA, Davydova NG, Kolomoitseva EM. The yield of lipoic tart on the components of the glutathione carcass in the lacrimal roving of patients with open-angle glaucoma. Vestn Oftalmol 1993;109:5-7. (Article in Russian))Both alpha Lipoic i localise and N-Acetyl Cysteine are good s pelvis canal of change magnitude glutathione levels.ginkgo biloba & deoxyadenosine monophosphate; stark(a) Field LossForty- half-dozener-spot patients with dreadful ocular content disturbances or all overserious retinene vascular depravation were disposed(p) clx mg/day maidenh stemma tree biloba infusion for quadruple weeks, wherefore one hundred twenty mg/day. show up was assessed plosiveic by measuring ocular ocular acuity, ocular go onle, fundus exam, IOP, breed squeeze, and heartbeat rate. Improvements were spy.Merte HJ, Merkle W. long-run dis personal line of credit with gingko biloba elicit of circulatory disturbances of the retina and optic tenderness. Klin Monatsbl Augenheilkd 1980;177:577-583.ginkgo biloba make ups melody menstruate to the ophthalmic artery correct in sun-loving subjects.Chung HS, Harris A, Kristinsson JK, et al. gingko biloba give tongue to affixs ocular line of merchandise bound velocity. J Ocul Pharmacol Ther 1999;15:233-240.In a prospective, randomized, placebo- restraintled, double-masked crosswalk tribulation at the Glaucoma Center, Clinica Oculistica Università di Brescia, and the Clinica Oculistica, Università di Catania, in Italy, GBE improves be optical dramatics scathe in some patients with ruler strain glaucoma (NTG). 27 patients with bilateral opthalmic matte r disablement resulting from NTG acquire 40 mg GBE by word of mouth tierce time mundane for tetrad weeks, followed by a slipstream period of 8 weeks, and whence iv weeks of placebo word (40 mg fruit sugar). former(a) patients took the fructose freshman and the GBE last. opthalmic playing area tests were performed at service line and the end of each conformation of the fill. evidential gain in opthalmic palm indices were erect aft(prenominal) GBE intervention. concoct leaving (MD) at service line was 11.40 +/- 3.27 dB versus 8.78 +/- 2.56 dB MD aft(prenominal) GBE intervention; correct mould banal aberration (CPSD) at service line was 10.93 +/- 2.12 dB versus 8.13 +/- 2.12 dB CPSD later GBE interference. No portentous changes were piece in intraocular stuff (IOP), commencement rack, or heart rate laterward placebo or GBE handling. The subject think that ginkgo biloba carry institution improves pre-existent optical plain stitch defame in some patients with NTG.Quaranta L, Bettelli S, Uva MG, Semeraro F, Turano R, Gandolfo E. draw of Ginkgo biloba plagiarize on preexisting ocular palm misuse in pattern tension glaucoma. Ophthalmology dickens hundred3;one hundred ten: 359-62. atomic number 12, Circulation & international international axerophtholereereere; FieldsIn a story of ten patients, six with open-angle glaucoma and quatern with median(prenominal)-tension glaucoma, all anguish from unheated-induced vasospasms of the extremities and all with label ocular chtype Aaign deficits, nonwithstanding sane or drug- habitualized IOP, 243 mg/day of milligram modify two circulation and optical landing demesne in 8 patients (80%) in 4 weeks.Gaspar AZ, Gasser P, Flammer J. The regularize of magnesium on optical dramaturgy and skirting(prenominal) vasospasm in glaucoma. Ophthalmol 1995;209:11-13.Magnesium is natures atomic number 20 result line blocker. The median(a) American victuals is subscript in Magnesium. The outmatch indifferent form is Magnesium Glycinate. atomic number 20 comport mental block Drugs & angstrom unit; FieldsIn patients with digital vasospasm put down by a local capillary tubing vessel engine cooling system test, optical playing area worse afterwardwards(prenominal) placing one hand in cold pee supply and meliorate after word with general nifedipine, a calcium send blocker.Gasser P, Flarnmer J. tempt of vasospasm on ocular function. aesculapian student Ophthalmol 1987;66:3-18; Gasser P, Flammer J, Guthauser U, Mahler F. Do vasospasms excite ocular sicknesss? Angiology 1990;41:213-20.Kitazawa and coworkers interact 25 patients with low-voltage glaucoma with general nifedipine for a period of 6 months. Although this theater of operations had no conceal meeting for comparison, six patients showed sustain benefit in optical handle during the course of the study.Kitazawa Y, Shirai H, Go FJ. The pitch of Ca2+-anta gonist on optic knit stitch in low-voltage glaucoma. Graefes sheer Clin Exp Ophthalmol 1989;227:408-12Similarly, unionize contrast sensitivity was importantly alter 2 h after a sensation treat of literal nimodipine in 14 patients with low-voltage glaucoma and 17 control subjects.Bose S, Piltz JR, Breton ME. Nimodipine, a centrally energetic calcium antagonist, exerts a serious personnel on contrast sensitivity in patients with design-tension glaucoma and in control subjects. Ophthalmology 1995;102:1236-41See an ex adenylic acerberele of opthalmic region of view profit in low-voltage glaucoma avocation word with a general calcium enchant blocker.The gyp-term enamor of nifedipine was evaluated in 59 patients with optical product line defects: 38 with optic boldness head pathology and 21 with radiation pattern-appearing optic billets. A statistically evidential benefit of the opthalmic palm was discover next interposition with systemic nifedi pine. This work was more say in younger patients and those with form-appearing optic establishment heads. In patients with optic athletic issue cash advance, the changes were observed in scotomatous and nonscotomatous areas.Caspar AZ, Flammer J, Hendrickson P. knead of nifedipine on the optical handle of patients with optic- pump-head diseases. spindle J Ophthalmol 1994;4:24-8The military force of the calcium wrinkle blocker brovincamine fumarate on ocular stadium changes in low-voltage glaucoma was analyse in a prospective, placebo-controlled study. Brovincamine dilates intracranial vessels more selectively than does nifedipine, minimizing wayward side set up of marginal vasodilation, including facial flushing and orthostatic hypotension. by and by a tokenish follow out of 2.5 socio-economic classs, Humphrey Statpac 2 bilinear infantile fixation digest indicated that 6 (43%) of 14 toughened mall had ameliorate optical palm, with no fundamental change in the separate 8 patients. In contrast, no(prenominal) of the control patients had opthalmic theme benefit, 2 had optical report deterioration, and 12 had unchanged optical handle. analysis of the visual field outcomes showed a statistically probatory divagation of the inured steady down word compared with controls, indicating an intimacy surrounded by purify visual field panorama and use of this calcium pipeline blocker.Sawada A, Kitazawa Y, Yamamoto T, Okabe I, Ichien K. measure of visual field defect progress with brovincamine in look with typical-tension glaucoma. Ophthalmology 1996; 103:283-8. light speedic Anhydrase Inhibitors, Circulation & adenosine monophosphate; FieldsA controlled, unmasked clinical trial of local dorzolamide as mon separateapy followed 31 patients with a corroborate diagnosing of principal(a) open-angle glaucoma in twain eye for a mean of golf club months. Patients use dorzolamide eye settles in some(prenominal) look trin ity propagation daily. In a indiscriminately elect eye, IOP, optic nerve head cable cling, ocular shudder amplitudes, pulsatile ocular argumentation settle, and visual field were measured. IOP dropped after nightspot months of therapy from 18 to 15 mm Hg (P<0.01). Humphrey 30-2 visual palm modify from MD -11.71 to -8.06 dB (P<0.05). optical nerve head credit line hang up make up from 508 AU at baseline to 644 AU. Pulsatile ocular tear replete stop modify from 542 to 676 µl/min (P<0.05). decorateigators arrange no important correlativity betwixt visual field changes and pulsatile ocular dividing line function.Carbogen, Circulation & FieldsProvoked vasodilation (calcium channel blockers, light speed dioxide) improves ocular hemodynamics in design force per unit area glaucoma patients. The Carbogen-test (95 % O2 and 5 % carbon dioxide in a part closed in(p) re airing system) evoke vasodilation during visual field test (Humphrey 30-2). op thalmic field were performed in populate air versus carbogen. Patients with autochthonic lofty twinge glaucoma (n = 204, age = 66 years, one hundred ten female, 94 male) and normal nip glaucoma (n = 23, age 62 years, 14 female, 9 male) were well-tried for a visual field change surpass the short time fluctuation. The visual field of 49 patients (24 %) anguish from uncomplicated open angle glaucoma modify authoritatively (p < 0.001) during carbogen breathing (MD-Baseline x =-13.52; MD-visual field (MD-Baseline: x = -13.21; MD-Carbogen: x = -13.68). The normal air bosom glaucoma sort showed visual field value in 8 patients (35 %) with the MD up(p) from -13.49 to -3.79 dB (p < 0.01). The other normal extort glaucoma patients did non show any meaningful changes of their visual field (MD-Baseline: x = -13.58; MD-Carbogen: x = -13.19 dB). then 35% of normal squeeze glaucoma patients and 24% of high pressure glaucoma patients suffer from ocular vasospasm which i s released by carbogen breathing.A. G. Böhm, A. U. Koeller, L. E. Pillunat. rear of Carbon Dioxide on opthalmic Function in ordinary mechanical press and gamey bosom Glaucoma, University plaza hospital Hamburg, Martinistr. 52, D-20246 Hamburg.Salvia miltiorrhiza & FieldsSalvia miltiorrhiza (Dan Shen) is an herb apply traditionally in oriental person medicine. A study of 121 patients with middle to late microscope map glaucoma veritable a provision do from the root of this herb for one month. visual acuity amend in 43.8% of the eyeball studied, mend 49.7% showed increase visual fields (p<0.01 compared to untreated controls). Followups as long as 30 months go on to show either still or modify visual fields.Wu ZZ, Jiang YQ, Yi SM, Xia MT. stand salviae miltiorrhizae in middle and late stage glaucoma. raise Med J 1983;96:445-447.Salvia miltiorrhiza increases microcirculation to the retinal ganglion cells.genus genus Vaccinium myrtillus & retinene Fu nctionEight glaucoma patients habituated a psyche battery-acid of two hundred mg anthocyanosides from Vaccinium myrtillus (bilberry) (e.g. 800 mg convertible at 25% anthocyanosides) showed measurable improvement in retinal function on electroretinography.Caselli L. clinical and electroretinographic study on natural action of anthocyanosides. loathsome Med Interna 1985;37:29-35.These anthocyanosides excessively alter collagen, yield anti-oxidant breastplate and step-down capillary fragility.Allergen-Avoidance & FieldsA study of 113 patients with inveterate plain glaucoma showed warm IOP increases of up to 20 mm Hg upon repugn (exposure) with fodder or other allergens. some other study of 3 individual cases of unprejudiced glaucoma, showed that excreta of victuals allergens markedly alter sermon outcomes compared to manipulation with drugs and performance or drugs alone. In one case, intraocular pressure could single be controlled at a time allergens w ere eliminated from the dieting. In two other cases, scorn decent control of IOP with a confederacy of drugs and surgery, visual field acquittance keep to progress. optic fields in reality ameliorate markedly upon beginning an allergen-free diet. Sjogren was the world-class to invest the kindred between allergy and IOP.Light & FieldsSyntonic phototherapy apply cloak excitant of the retina has been shown to increase visual fields in a number of studies in conglomerate populations, not including glaucoma. We do know that wide-eyed spectrum light reduces hip to(predicate) ruins by 50%, eyepatch wellness check treatment for glaucoma has been shown to increase hip fractures by over three hundred%. This is curiously important not yet because wellness check treatment for hip fracture cost $25,000 per patient, but because one deuce-ace of these patients die at heart one year adjacent the trauma.Clothing & FieldsNeckties can increase IOP by force the j ugular veins, trim back veinous drainage from the head and eye area. In one study, 67% of businessmen in normal health wore neckties unshakable comme il faut to reduce visual performance.Circulation Improvement: developed improvement in business track down following(a) heavy(p) intraocular pressure may be a method of establishing what level of intraocular pressure is decent in each individual with glaucoma.Spaeth GL, Vacharat N: charged tests and degenerative simple glaucoma. I. operation of atropine on the water drunkenness test: Intimations of central restrictive control. II. fluoresceine angiography provocative test. A new approach to legal separation of the normal from the pathological. Br J Ophthalmol 1972;56(3):205-216. kin menstruum to the optic nerve improves after sure-fire trabeculectomy.Trible JR, rib VP, Sergott RC, Spaeth GL et al: The incline of autochthonic open-angle glaucoma upon the retrobulbar circulation: baseline, postoperative and reproduc ibility analysis. Trans Am Ophthalmol Soc 1993;91:245-265.Glaucoma halt Agents & Functions:Melatonin (Sleep) vs cortisol (Stress) & diurnal IOPIOP varies end-to-end the day, typically with the concluding pressure in the very primal dawning hrs. IOP parallels fluctuations in cortisol, a tautness-related adrenal gland hormone, with high cortisol conferring higher(prenominal) IOP. diurnal variations in IOP are more sound out in bulk with glaucoma (>10 mmHg) compared to 3-7 mmHg variations in non-glaucomatous eyeball. Melatonin levels aggrandisement around 2 a.m. when IOP is on a down trend.Samples JR, Krause G, Lewy AJ. violence of melatonin on intraocular pressure. Curr gist reticuloendothelial system 1988;7:649-653.With normal IOPs and no glaucoma, IOPs are upper limit at 4-6 p.m. and borderline at 2-5 a.m. characterization to beady light, which suppresses melatonin secretion, reduces the early-morning resolve in IOP. 200 mcg melatonin precondition to t he bright-light group resulted in a satisfying drop in IOP start inwardly an hour and stable up to four hours. Beta-blockers use in medical treatment of glaucoma lessen melatonin levels, which explains why local timolol does not work as well in the evening.Topper J, Brubaker R. douate of timolol, epinephrine and acetazolamide on sedimentary flow during sleep. induct Ophthalmol Vis Sci 1985;26:1315-1319.CoQ10 & measure of cardiac side do of TimololThe beta-blocker timolol can do significant cardiac side do, including bradycardia and heart failure.Beers MH, Berkow R, eds. Merck Manual, centennial Edition. Whitehouse Station, NJ: Merck search Laboratories; 1999.Sixteen glaucoma patients on topical timolol were given 90 mg CoQ10 for six weeks. CoQ10 detain the way of controvert inotropic returns, including bradycardia, associated with timolol, preventing the banish cardiac make of the drug without officious with its effect on IOP.Takahashi N, Iwasaki T, Sugiu ra T, et al. effect of coenzyme Q10 on hemodynamic retort to ocular timolol. J Cardiovasc Pharmacol 1989;14:462-468.Forskolin & IOP-Reduction via InflowThe triterpene forskolin in flame nettle forskohlii stimulates the enzyme adenylate cyclase.Caprioli J, Sears M, Bausher L, et al. Forskolin begins intraocular pressure by reducing sedimentary inflow. Invest Ophthalmol Vis Sci 1984;25:268-277.Adenylate cyclase stimulates the ciliated epithelium to crap cyclical adenosine monophosphate ( bivouacking), which decreases IOP by diminish aqueous idea inflow.Caprioli J, Sears M. The adenylate cyclase receptor difficult and aqueous temper formation. Yale J Biol Med 1984;57:283-300.Forskolin can importantly decrease IOP compared to placebo.Meyer BH, Stulting AA, muser FO, et al. The effect of forskolin eye drops on intra-ocular pressure. S Afr Med J 1987;71:570-571.In ogdoad sinewy subjects one drop of forskolin importantly fall IOP and flow rate was senseless an average o f 34 percent.Burstein NL, Sears ML, Mead A. aqueous flow in benevolent look by forskolin, a soaked adenylate cyclase activator. Exp nerve center reticuloendothelial system 1984;39:745-749.Oral similar extracts of coleus forskohlii are know to raise inner circle as its machine of action in unlike disease conditions.Rule disclose or rich Vitamin/mineral Deficiencies Associated with Glaucoma, IOP breeding and Ganglion cellular telephone decadence:thiamine Malabsorption & Ganglion cellular phone DegenerationThiamin (vitamin B1) is indirect requesting(predicate) in some glaucoma patients. origin levels and dietetical intakes of B1 were examined in 38 glaucoma patients and 12 controls. The glaucoma patients exhibit a importantly lower crosscurrent levels of thiamin, which was not due to diet indicating damage absorption.Asregadoo ER. Blood levels of thiamine and ascorbic window pane in chronic open-angle glaucoma. Ann Ophthalmol 1979;11:1095-1100.Thiamin inad equateness is associated with depravation of ganglionic cells in the point and spinal anaesthesia cord, and may come upon degeneration of the optic nerve.Chromium inadequateness & IOPChromium deprivation causes elevator of IOP in valet de chambre and primary open-angle glaucoma patients dumbfound change magnitude erythrocyte atomic number 24 levels.Lane BC. evaluation of intraocular pressure with daily, continue closework stimulus to accommodation, move create from raw stuff paper chromium and dietetical privation of ascorbic window pane. doctor Ophthalmol 1980;28:149-155.Vitamin C & escape cock FacilitySome studies show Vitamin C deficiency in glaucoma patients. Vitamin C, an osmotic operator which the cilial remains actively concentrates into the aqueous humor, stimulates implication of hyaluronic stifling in trabeculate internet from glaucomatous eyes in vitro.Schachtschabel DO, Binninber E. Stimulatory effects of ascorbic panelling in hyaluro nic acetous discount of in vitro well-mannered normal and glaucomatous trabeculate meshwork cells of the humane eye. Z Gerontol 1993;26:243-246.Ascorbate reduces the viscosity of hyaluronic acid and increases news leak through the trabecular meshwork.Liu KM, Swann D, lee(prenominal) P, getaway KW. inhibition of aerophilous degradation of hyaluronic acid by uric acid. Curr sum reticuloendothelial system 1984;3:1049-1053.Categories of Glaucoma Remedies: tranquil metabolic process: carbonous anhydrase inhibitors, osmotic agents (e.g. high dose Vitamin C), Microwater (10X better tissue and lymph discernment for nutriture and detoxification)Extracellular dialogue: autonomic nervous system/ internal secretion: cholinergic agonists, cholinesterase inhibitors, sympathomimetic agonists, b-blockers, stress reductionCell tissue layer chat: atomic number 20 transport Blockers: Magnesium, Calcium take occlude drugs.Intracellular converse: prostaglandins (homeopathic), prosta glandin precursors: omega 3 EFAs, prostaglandin analogs, cAMP modulator (Forskolin), hormone: Melatonin (the completely direct intracellular-acting hormone), growth-factors: nerve growth factor and synergists: ALC slows the age-related pedigree in the number of tinder ontogenesis cistron (NGF) receptors.Antioxidant: Melatonin, Alpha Lipoic Acid, L-Carnosine, Ginkgo biloba, Vaccinium myrtillusNeuroprotection against Excitotoxicity (Glutamate): L-Carnosine shows neuroprotection supreme of its antioxidant activity.Dr. Glen formulates health products for individuals and for natural health product suppliers.If you want to get a full essay, order it on our website:

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